研究業績(2004年)

論文

○Abe K, Noguchi H, Tagawa K, Yuzuriha M, Toyoda A, Kojima T, Ezawa K, Saitou N, Hattori M, Sakaki Y, Moriwaki K, Shiroishi T. Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC end sequence? SNP analysis. Genome Res 14: 2439-2447, 2004.

○Fukuma G, Oguni H, Shirasaka Y, Watanabe K, Miyajima T, Yasumoto S, Ohfu M, Inoue T, Watanachai A, Kira R, Matuo M, Munakata H, Sofue F, Zhang B, Kaneko S, Mitsudome A, Hirose S. Mutations of neuronal voltage-gated Na+ channel α1 subunit gene SCN1A in core severe myoclonic epilepsy in infancy (SMEI) and in borderline SMEI(SMEB). Epilepsia 45(2): 140-148, 2004.

○Gang Z, Okada M, Yoshida S, Hirose S, Kaneko S. Determination of exocytosis mechsnisms of DOPA in rat striatum using in vivo microdialysis. Neurosci Lett 367: 241-245, 2004.

○Hirose N, Arai Y, Gondoh Y, Nakazawa S, Takayama M, Ebihara Y, Shimizu K, Inagaki H, Masui Y, Kitagawa K, Kojima T. Tokyo Centenarian Study: Aging inflammation hypothesis. Geriatrics & Gerontology International 4: s182-185, 2004.

○Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa TO, Taketo MM, Fukuda A, Kawakami K. Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci 24(47): 10693-10701, 2004.

○Inoue K, Ueno S, Fukuda A. Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase. FEBS Lett 564(1-2): 131-135, 2004.

○Ito M, Shirasaka Y, Hirose S, Sugawara T, Yamakawa K. Seizure phenotypes of a family with missense mutations in SCN2A. Pediatr Neurol 31(2): 150-152, 2004.

○Kamiya K, Kaneda M, Sugawara T, Mazaki E, Okamura N, Montal M, Makita N, Tanaka M, Fukushima K, Fujiwara T, Inoue Y, Yamakawa K. A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. J Neurosci 24: 2690-2698, 2004.

○Kanai K, Hirose S, Oguni H, Fukuma G, Shirasaka Y, Miyajima T, Wada K, Iwasa H, Yasumoto S, Matsuo M, Ito M, Mitsudome A, Kaneko S. Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity. Neurology 63(2): 329-334, 2004.

○Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N. Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp Gerontol 39: 1595-1598, 2004.

○Murakami K, Kojima T, Sakaki Y. Assessment of clusters of transcription factor binding sites in relationship to human promoter, CpG islands and gene expression. BMC Genomics 5: 16, 2004.

○Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, Zhu G, Kasagi Y, Kamiya H, Harada A, Nishimura K, Takeuchi A, Miyazaki T, Watanabe M, Yasa D, Manabe T, Wakabayashi K, Kaneko S, Saito T, Ohno H. Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol 167(2): 293-302, 2004.

○Okada M, Gang Z, Yoshida S, Hirose S, Kaneko S. Pharmacological discrimination of protein kinase associated exocytosis mechanisms between dopamine and DOPA in rat striatum using in vivo microdialysis. Neurosci Lett 363: 120-124, 2004.

○Okada M, Gang Z, Yoshida S, Hirose S, Kaneko S. Protein kinase associated with gating and closing transmission mechanisms in temporoammonic pathway. Neuropharmacology 47?F485-504, 2004.

○ Okada M, Zhu G, Yoshida S, Hirosa S, Kaneko S. Protein kinase associated with gating and closing transmision mechanisms in temporoammonic pathway. Neuropharmacol 47(4): 485-504, 2004.

○Suzuki T, Delgado-Escueta VA, Aguan K, Alonso EM, Shi J, Hara Y, Nishida M, Numata T, Medina TM, Takeuchi T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey NJ, Ochoa A, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K. Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet 36(8): 842-849, 2004.

○Yasui-Furukori N, Furukori H, Kaneda A, Kaneko S, Tateishi T. The effects pof ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil. J Clin Pharmacol 44: 538-542, 2004.

○Yasui-Furukori N, Mihara K, Takahata T, Suzuki A, Nakagami T, Vries R, Tateishi T, Kondo T, Kaneko S. Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lach of impact of MDR-1 genotypes. Int Clin Psychophartmacol 19(3): 178-179, 2004.

○Zhu G, Okada M, Uchiyama D, Ohkubo T, Yoshida S, Kaneko S. Hyperactivity of endoplasmic reticulum associated exocytosis mechanism contributes to acute phenylclidine intoxication. J Pharmacol Sci 95: 214-227, 2004.

○Zhu G, Okada M, Yoshida S, Hirose S, Kaneko S. Both 3,4-dihydroxyphenylalanine and dopamine releases are regulated by Ca2+-induced Ca2+ releasing system in rat striatum. Neurosci Lett 362(3): 244-248, 2004.

○Zhu G, Okada M, Yoshida S, Hirose S, Kaneko S. Pharmacological discrimination of protein kinase associated exocytosis mechanisms between dopamine and 3,4-dihydroxyphenylalanine in rat striatum using in vivo microdialysis. Neurosci Lett 363(2): 120-124, 2004.


学会発表

・国内(シンポジウム・ワークショップ等)

○兼子 直,ワークショップ:てんかんの診断と治療ガイドライン, てんかんを持つ妊娠可能婦人の管理ガイドライン,第38回日本てんかん学会,静岡市,2004.09.30−10.01

○兼子 直,妊娠中のてんかん治療 −抗てんかん薬と催奇性−,第45回日本神経学会総会,東京都,2004.05.14

○兼子 直,シンポジウム3「てんかんの分子生物学」 てんかんの遺伝子,第39回脳のシンポジウム,東京都,2004.03.13-14

○兼子 直,古郡規雄,合同シンポジウム:薬理遺伝学の新展開 テーラーメード医療を目指して Clinical pharmacogenetics in psychiatric field 精神科領域におけるクリニカルファルマコゲネティクス,第34回日本神経精神薬理学会,第26回日本生物学的精神医学会合同年会,東京都,2004.07.21-23

○兼子 直,てんかんの分子病態,第12回脳の世紀シンポジウム,東京都,2004.09.15


・国内(口頭発表)

○兼子 直,岡田元宏,朱  剛,金井数明,福間五龍,廣瀬伸一,小島俊男,伊藤正利,小国弘量,The Epilepsy Genetic Study Group, Japan",熱性けいれん,熱性けいれんプラス,及び乳児重症ミオクロニーてんかんの遺伝子解析と遺伝子診断の設定,第16回(財)てんかん治療研究振興財団研究報告会,大阪府,2004.08.06

○朱  剛,岡田元宏,吉田淑子,中津 史,森 秋文,若林孝一,大野博司,兼子 直,AP3Bノックアウトマウス自発性けいれん発現機序解明(第3報)−海馬モノアミン遊離機構の解析,第38回日本てんかん学会,静岡市,2004.09.30−10.01

○金井数明,廣瀬伸一,小国弘量,福間五龍,白坂一義,宮島 祐,和田一丸,岩佐博人,安元佐和,松尾宗明,桑原 聡,伊藤正利,服部孝道,満留昭久,兼子 直,GEFS + SMEIで認められるSCN1Aミスセンス変異の表現型 −遺伝子型相関に関するメタ解析,第38回日本てんかん学会,静岡市,2004.09.30−10.01

○鈴木俊光,Delgado-Escueta Antonio V, Aguan Kripamoy, Shi Jun, 原 雄二,西田基宏,沼田朋大,竹内 環,Dong-Sheng Bai, 井上有史,大澤真木子,兼子 直,小国弘量,森 泰生,山川和弘",若年生ミオクロニーてんかん(JME)責任遺伝子の同定,第38回日本てんかん学会,静岡市,2004.09.30−10.01

○兼子 直,岩佐博人,岡田元宏,古郡規雄,朱  剛,和田一丸,金井数明,廣瀬伸一,てんかんの責任遺伝子探索と遺伝子(多型)に基づいた個別化治療の開発,平成16年度厚生労働省精神・神経疾患委託費『てんかんに対する内科・外科的治療に関する総合的研究』班会議,東京都,2004.12.17


国内(ポスター発表)

○岡田元宏,朱  剛,吉田淑子,兼子 直,ヒト中枢神経系機能性疾患遺伝子を導入した遺伝子改変モデル動物の作出,第37回精神神経系薬物治療研究報告会,豊中市,2004.12.10