研究業績(2006年)

論文

○Arai Y, Nakazawa S, Kojima T, Takayama M, Ebihara Y, Shimizu K, Yamamura K, Homma S, Osono Y, Gondo Y, Masui Y, Inagaki H, Kitagawa K, Hirose N. High adiponectin concentration and its role for longevity in female centenarians. Geriatrics & Gerontology International 6(1): 32-39, 2006.

○Du Y, Hirose N , Ping J, Ishida Y, Kojima T, Arai Y, Inagaki H, Gondo Y, Sakaki Y, Haneda M, Ito S, Isobe K. Analysis of growth hormone receptor polymorphism in Japanese semi-super centenarians. Geriatrics & Gerontology International 6(2): 82-86, 2006.

○Hirose S. A new paradigm of channelopathy in epilepsy syndromes: Intracellular trafficking abnormality of channel molecules. Epilepsy Res 70: 206-217, 2006.

○Inoue K, Yamada J, Ueno S, Fukuda A. Brain-type creatine kinase activates neuron-specific K+-Cl- co-transporter KCC2. J Neurochem 96(2): 598-608, 2006.

○Ito M, Yamakawa K, Sugawara T, Hirose S, Fukuma G, Kaneko S. Phenotypes and genotypes in epilepsy with febrile seizures plus. Epilepsy Res 70S: S199-205, 2006.

○Kanaumi T, Takashima S, Hirose S, Kodama T, Iwasaki H. Neuropathology of amethylmalonic acidemia in a child. Pediatr Neurol 34: 156-159, 2006.

○Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakaki Y, Kaneko S. Determination of Genomic Breakpoints in an Epileptic Patient Using Genotyping Array. Biochem Biophys Res Commun 341(3): 792-726, 2006.

○Niioka T, Yasui-Furukori N, Uno T, Sugawara K, Kaneko S, Tateishi T. Identification of a shingle time-point for plasma lansoprazole measurement that adequately reflects area under the concentration-time corve. Ther Drug Monit28(3):321-325, 2006.

○Rabello D, Soedarsono N, Kamei H, Ishihara Y, Noguchi T, Fuma D, Suzuki M, Sakaki Y, Yamaguchi A, Kojima T. CSF1 gene associated with aggressive periodontitis in the Japanese population. Biochem Biophys Res Commun 347(3): 791-796, 2006.

○Sasaki T, Ryan PR, Delhaize E, Hebb DM, Ogihara Y, Kawaura K, Noda K, Kojima T, Toyoda A, Matsumoto H, Yamamoto Y. Sequence upstream of the wheat (Triticum aestivum L.) ALMT1 gene and its relationship to aluminum resistance. Plant Cell Physiol 47(10): 1343-1354, 2006.

○Singh B, Ogiwara I, Kaneda M, Tokonami N, Mazaki E, Baba K, Matsuda K, Inoue Y, Yamakawa K. A Kv4.2 truncation mutation In a patient with temporal lobe epilepsy. Neurobiology of Disease 24: 245-253, 2006.

○Soedarsono N, Rabello D, Kamei H, Fuma D, Ishihara Y, Suzuki M, Noguchi T, Sakaki Y, Yamaguchi A, Kojima T. Evaluation of RANK/RANKL/OPG Gene Polymorphism in Aggressive Periodontitis. J Periodont Res 41: 397-405, 2006.

○Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S. Co-localization of ?A-peptide and phosphorylated tau in astrocytes in a patients with corticobasal degeneration. Neuropatology 26(1): 66-71, 2006.

○Yamauchi T, Kaneko S, Yagi K, Sase S. Treatment of partial seizure with gabapentin: Double-blind, placebo-controlled, parallel-group study. Psychiatry Clinical Neurosciences 60:507-515, 2006.

○Yasui-Furukori N, Kaneko S. Digitalis intoxiction induced by paroxetine co-administration. Lancet 367: 788, 2006.

○Yasui-Furukori N, Saito M, Nakagami T, Kaneda A, Tateishi T, Kaneko S. Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: A preliminary study. Prog Neuro-Psychopharmacol Biol Psychiatr 30: 286-291, 2006.

○Yasui-Furukori N, Uno T, Kaneko S, and Tateishi T. Autho's reply: Hydroxylation of lansoprazole in poor metabolizers of CYP2C19. British Journal of Clinical Pharmacology 61(3):361-362, 2006.

○Yasui-Furukori N, Uno T, Kaneko S, Tateishi T. Autho's reply: Hydroxylation of lansoprazole in poor metabolizers of CYP2C19. Brit J Clin Pharmacol 61(3): 361-362, 2006.

○Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S. Involvement of Ca2+-induced Ca2+ releasing system in interleukin-1?A-associated adenosine release. Eur J Pharmacol 532: 246-252, 2006.

○Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S. Effects of interleukin-1?Aon hippocampal glutamate and GABA releases associated wuth Ca2+-induced Ca2+ releasing systems. Epilepsy Res 71: 107-116, 2006.

学会発表

・国際(ポスター)

○Zhu Gang, Okada Motohiro, Yoshida Shukuko, Wakabayashi Koichi, and Kaneko Sunao",Interleukin-1β leads overload response of Ca2+ mobilisation resulting in an imbalance between glutamatergic and GABAergic tranmission in the hippocampus.,6th Asian & Oceanian Epilepsy Congress,"Kuala Lumpur, Malasia",2006.08.16-19,,

○Murasaki M, Yagi K, Yamauchi T, Kameyama S, Kaneko Sunao, Lucas M, and Tonner Multicentre, Double-blind, randomised, plasebo-controlled, parallel-group study of add-on levetiracetam in Japanese patients with uncontrolled partial seizures. ",6th Asian & Oceanian Epilepsy Congress,"Kuala Lumpur, Malasia",2006.08.16-19,,


・国内(シンポジウム・ワークショップ等)

○兼子 直,抗てんかん薬と催奇形性,第65回日本脳神経外科学会総会,京都市,2006.10.20,,

○兼子 直,臨床精神薬理学セミナー: てんかんの薬物療法,第16回日本臨床精神神経薬理学会,北九州市,2006.10.25-27,

○兼子 直,シンポジウム: てんかん発作発現前の脳可逆性変化とてんかん原性,第29回日本神経科学大会,京都市,2006.7.19-21,,

○兼子 直,シンポジウム1: てんかんの分子遺伝学研究 Introduction−てんかんの分子遺伝学的研究−,第40回日本てんかん学会,金沢市,2006.09.28-29,


・国内(口頭発表)

○朱  剛,岡田元宏,吉田淑子,若林孝一,兼子 直,IL-1βおてんかん原性機序:海馬アデノシン遊離に対する効果の検討,第40回日本てんかん学会,金沢市,2006.09.28-29,,

○岡田元宏,吉田淑子,朱  剛,上野伸哉,兼子 直,細胞内カルシウム放出機構(CICR)に対する抗てんかん薬ゾニサミドの効果,第40回日本てんかん学会,金沢市,2006.09.28-29,

○岡田元宏,朱  剛,吉田淑子,上野伸哉,兼子 直,ヒト機能性神経精神疾患の遺伝子治療法開発に関わる基礎研究,第39回精神神経系薬物治療研究報告会,豊中市,2006.12.08,

○兼子 直,岩佐博人,古郡規雄,岡田元宏,土嶺章子,佐々木智美,廣瀬伸一,伊藤正利,小国弘量,大澤真木子,前澤真理子,小島俊男,金井数明,和田一丸,てんかんの責任遺伝子探索と遺伝子多型に基づいた個別化治療の開発,国立精神・神経センター受託研究 平成18年度藤原班会議,東京都,2006.12.15,


国内(ポスター発表)

○古郡規雄,鈴木友和,登  勉,水野雅文,白濱秀也,三好康弘,兼子 直,日本人におけるCYP2C19および2D6のアレル頻度について,第27回日本臨床薬理学会年会,東京都,2006.11.29-12.01,